Use of Proteomics for the Diagnosis of a Platelet-related Bleeding Disorder
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 4
- Locations
- 1
- Primary Endpoint
- Levels of detectable platelet proteins
Study Overview
Brief Summary
The goal of this study is to identify the platelet defect responsible for the bleeding in families from our inherited platelet disorders Israeli-Palestinian registry. The investigators plan to characterize platelet proteome expression after removing high abundance proteins. The investigators will compare the proteome of sick and healthy members of families with inherited platelet disorders, and identify and validate structural proteins, signaling cascades and biomarkers for detection and diagnosis of unknown platelet disorders. The investigators expect to discover new key findings that allow better understanding of human platelet function and allow better diagnosis and treatment of patients with inherited platelet function disorders.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 3 Years to 85 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •History of inherited platelet disorders in the family
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Levels of detectable platelet proteins
Time Frame: 2014-2015 (1 year)
Characterize platelet proteome expression profile
Secondary Outcomes
- Changes in protein expression from sick and healthy platelets(2015-2019 (4 years))
Investigators
Ela Shai
Researcher at Hadassah Medical Center
Hadassah Medical Organization