Use of Proteomics for the Diagnosis of a Platelet-related Bleeding Disorder

Not Applicable

Completed

• Conditions: Inherited Platelet Disorders

• Registration Number: NCT02096523
• Lead Sponsor: Ela Shai

Brief Summary

The goal of this study is to identify the platelet defect responsible for the bleeding in families from our inherited platelet disorders Israeli-Palestinian registry. The investigators plan to characterize platelet proteome expression after removing high abundance proteins. The investigators will compare the proteome of sick and healthy members of families with inherited platelet disorders, and identify and validate structural proteins, signaling cascades and biomarkers for detection and diagnosis of unknown platelet disorders. The investigators expect to discover new key findings that allow better understanding of human platelet function and allow better diagnosis and treatment of patients with inherited platelet function disorders.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-03-20
• Study First Submitted QC: 2014-03-23
• Study First Posted: 2014-03-26
• Study Start: 2016-11
• Primary Completion: 2021-01
• Study Completion: 2021-07
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-24
• Last Update Posted: 2021-08-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

• History of inherited platelet disorders in the family

Exclusion Criteria

• none

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Levels of detectable platelet proteins	2014-2015 (1 year)	Characterize platelet proteome expression profile

Secondary Outcome Measures

Name	Time	Method
Changes in protein expression from sick and healthy platelets	2015-2019 (4 years)	Analysis of platelet proteome of sick and healthy members of families with inherited platelet disorders

Trial Locations

Locations (1)

Hadassah Medical Organization; 🇮🇱 Jerusalem, Israel