Use of Proteomics for the Diagnosis of a Platelet-related Bleeding Disorder
- Conditions
- Inherited Platelet Disorders
- Interventions
- Other: Blood collection for platelet protein samples
- Registration Number
- NCT02096523
- Lead Sponsor
- Ela Shai
- Brief Summary
The goal of this study is to identify the platelet defect responsible for the bleeding in families from our inherited platelet disorders Israeli-Palestinian registry. The investigators plan to characterize platelet proteome expression after removing high abundance proteins. The investigators will compare the proteome of sick and healthy members of families with inherited platelet disorders, and identify and validate structural proteins, signaling cascades and biomarkers for detection and diagnosis of unknown platelet disorders. The investigators expect to discover new key findings that allow better understanding of human platelet function and allow better diagnosis and treatment of patients with inherited platelet function disorders.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 4
- History of inherited platelet disorders in the family
- none
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description platelet disease Blood collection for platelet protein samples patients with inherited platelet disorders Healthy Blood collection for platelet protein samples Healthy family members of patients with inherited platelet disorders
- Primary Outcome Measures
Name Time Method Levels of detectable platelet proteins 2014-2015 (1 year) Characterize platelet proteome expression profile
- Secondary Outcome Measures
Name Time Method Changes in protein expression from sick and healthy platelets 2015-2019 (4 years) Analysis of platelet proteome of sick and healthy members of families with inherited platelet disorders
Trial Locations
- Locations (1)
Hadassah Medical Organization
🇮🇱Jerusalem, Israel