Impact of the short chain fatty acid propionate on mesenteric adipose tissue, liver metabolism and insulin sensitivity: The PROMIS study

Imperial College London0 个研究点目标入组 56 人开始时间: 2023年7月27日最近更新: 2023年8月21日

试验速览

暂无简介。

•In vivo study:
•1. The participants on the waiting list for cholecystectomy
•2. Male or female
•3. Age between 18-75 years (inclusive)
•4. Body mass index (BMI) of 18-35 kg/m2
•5. Willingness and ability to give written informed consent and willingness and ability to understand, participate and comply with the study requirements
•In vitro study:
•1. The participants on the surgery waiting list of the team with Dr Madhava Pai
•2. Male or female
•3. Age between 18-75 years (inclusive)
•4. Body mass index (BMI) of 18-35 kg/m2
•5. Willingness and ability to give written informed consent and willingness and ability to understand, participate and comply with the study requirements

•In vivo study:
•1. Abnormal ECG
•2. Screening blood results outside of normal reference values
•3. Weight change of =3 kg in the preceding 2 months
•4. Current smokers
•5. History of substance abuse and/or excess alcohol intake
•6. Pregnancy
•7. Formal medical diagnosis of Type 2 Diabetes, Cardiovascular disease, Cancer, Gastrointestinal disease (e.g. inflammatory bowel disease or irritable bowel), Kidney disease, Liver disease and Pancreatitis
•8. Participation in a research study in the 12-week period prior to entering this study
•9. Any blood donation within the 12-week period prior to entering this study
•10. Use of antibiotics in the past 3 months
•11. New medication in the past 3 months
•12. Any other reason in the opinion of the investigator
•In vitro study
•1. Screening blood results outside of normal reference values
•2. Weight change of = 3kg in the preceding 2 months
•3. History of substance abuse and/or excess alcohol intake
•4. Pregnancy
•5. Any other reason in the opinion of the investigator

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