PVI for TVC Response

• Conditions: Validation of PVI in Tidal Volume Challenge Test

• Registration Number: NCT04978909
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Determine the ability of changes in Plethysmographic Variability Index during tidal volume challenge to predict fluid responsiveness

Detailed Description

The change of Plethysmographic Variability Index after tidal volume challenge as a predictor of fluid responsiveness, confirmed with the change of SVV using Flotrac advance cardiac output monitor.

To determine whether the patient is fluid responder, Fluid challenge will be performed afterwards to confirm the patient's fluid responsiveness.

We also aim to calculate the least significant change for Plethysmographic Variability Index and Philips PPV system.

Study Timeline

• Status Verified: 2021-07
• Study Start: 2021-07
• Study First Submitted: 2021-07-18
• Study First Submitted QC: 2021-07-18
• Last Update Submitted: 2021-07-18
• Study First Posted: 2021-07-27
• Last Update Posted: 2021-07-27
• Primary Completion: 2022-07
• Study Completion: 2022-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The predictive ability of change in Plethysmographic Variability Index after Tidal volume challenge to predict fluid responsiveness	20 minutes	The change in value of Plethysmographic Variability Index after increasing VTE from 6 ml/kg to 8 ml/kg.

Secondary Outcome Measures

Name	Time	Method
Least significant change for Massimo PVI and Philips PPV	20 minutes	Calculate the least significant change for Massimo PVI and Philips PPV using data acquired from our electronic system

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei City, Taiwan