A prospective view on disease course and associated biomarkers in Hereditary Cerebral Hemorrhage With Amyloidosis Dutch type (HCHWA-D)

Recruiting

• Conditions: HCHWA-D; 10007963; hereditary cerebral amyloid angiopathy; Hereditary Cerebral Hemorrhage With Amyloidosis Dutch type

• Registration Number: NL-OMON55383
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

1. Age >= 18y
2. Presence of either the APP mutation or an (earlier occurrence of) ICH on
CT/MRI suspect for CAA and a family history (first degree relative) of HCHWA-D.
3. Ability and willingness to provide written informed consent

Additional criteria for TRACK D-CAA subgroup:
1. Age 25-60 (inclusive) years old
2. Presence of APP mutation at position 693 (100% carrier) or one first-degree
relative with the mutation (50% carrier in case participants do not want to
know their mutation status)
3. No symptomatic ICH or maximum of 1 symptomatic ICH > 1 year before study
entry with ADL independence after the hemorrhage.

Exclusion Criteria

1. Contra-indications for 3T/7T MRI as determined by the 7Tesla safety
committee. (exclusion for a subpart of the study)
2. Contraindications for lumbar puncture (exclusion for a subpart of the study)
3. Contraindications for [18F]Florbetaben PET-CT (TRACK D-CAA subgroup only)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified