Early and late effects of 24 hours supplemental parenteral amino acids on whole-body protein turnover in critically ill patients.
Not Applicable
Completed
- Conditions
- critical illnessDiet and Nutrition - Other diet and nutrition disordersMetabolic and Endocrine - Other metabolic disorders
- Registration Number
- ACTRN12615001314516
- Lead Sponsor
- Olav Rooyackers
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Critically ill patients with expected stable nutrition for 30 hours.
Exclusion Criteria
Ongoing dialysis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Whole-body protein balance.<br><br>Whole-body protein balance is calculated by the difference between whole-body protein synthesis and breakdown rates which are assessed by the infusion of stable isotope labelled phenylalanine and tyrosine, detection of its amounts in plasma of the patients by mass spectrometry and kinetic modelling.[Whole-body protein balance measured just before (baseline) and at 3 and 24 hours after start of the intervention.]
- Secondary Outcome Measures
Name Time Method Whole-body phenylalanine oxidation.<br><br>Whole-body phenylalanine is calculated from the decarboxylation rate which is assessed by the infusion of stable isotope labelled phenylalanine and tyrosine, detection of its amounts in plasma of the patients by mass spectrometry and kinetic modelling.[Whole-body phenylalanine oxidation will be measured just before (baseline) and at 3 and 24 hours after start of the intervention.];Plasma amino acid profile.<br><br>Plasma amino acid profile is measured by established HPLC technique on plasma samples from the patients. [Plasma amino acid profile is measured just before (baseline) and at 3 and 24 after start of the infusion.]