Automatic Detection of Dyspnea in Mechanically Ventilated, Critically Ill Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Correlation between the pressure-time-product of inspiratory effort and the MV-RDOS score.
Study Overview
Brief Summary
The investigators will conduct a prospective, observational, two-center ICU study of 60 subjects on mechanical ventilation with respiratory failure of any cause.
Detailed Description
Inclusion criteria:
- Adults of either sex (≥18 years)
- Non-c0mmunicative, endotracheally intubated in the past 24 hours.
- Expected to require ≥24 hours of mechanical ventilation.
Exclusion criteria:
- Continuous neuromuscular blockade.
- Ventilated on Airway Pressure Release Ventilation mode.
Ventilator measured airway pressure and flow signals will be streamed at 31.25 Hz into 131.1-s time windows (epochs) for up to 5 days. A recursive algorithm will compute individual breath's inspiratory effort (Pmus) and calculate the inspiratory effort time-pressure product (PmusPTP cmH₂O·s·min-¹).
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Correlation between the pressure-time-product of inspiratory effort and the MV-RDOS score.
Time Frame: One year
The degree of correlation between the pressure-time-product of inspiratory effort and the MV-RDOS score will be determined with Pearson's coefficient of determination (R2).
Secondary Outcomes
- Ventilator free days.(One year)
Investigators
Celica Irrazabal
Director, Intensive Care Unit and Co-Principal Investigator
Hospital de Clinicas José de San Martín