Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome

Completed

• Conditions: Dravet Syndrome

• Registration Number: NCT02896608
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-10-29
• Study First Submitted: 2016-08-23
• Study First Submitted QC: 2016-09-06
• Study First Posted: 2016-09-12
• Primary Completion: 2019-10-16
• Study Completion: 2019-10-16
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-14
• Last Update Posted: 2023-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

• early infantile epileptic encephalopathy with HCN1 channel mutation
• control patients with no neurologic pathology (age, gender and body temperature matched)
• epileptic patients (age, gender and body temperature matched)

Exclusion Criteria

• pregnant or breast feeding patient

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
hyperpolarizing electrotonus	baseline
hyperpolarizing threshold current	baseline

Trial Locations

Locations (1)

Fondation Ophtalmologique Adolphe de Rothschild; 🇫🇷 Paris, France