Associations Among Serum and Gastric Juice Bile Acid Profile, Bile Acid-microbiota Cross-talk in Stomach and the Development of Gastric Cancer: A Case-control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 73
- 试验地点
- 1
- 主要终点
- corelation between the bile acid profile and gastric mucosa diseases
研究概览
简要总结
To explore the associations among bile acid profile, bile acid-microbiota cross-talk and the development of gastric cancer, so as to better prevent the occurrence and development of gastric cancer
详细描述
This study is a case-control study. Patients, according to the pathological results, will be consecutively enrolled and divided into gastric cancer group, gastric precancerous lesions group, and chronic gastritis group. The serum and gastric juice bile acid profiles, gastric microbial composition of each group patients will be detected.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 to 75 years old, gender is not limited;
- •No history of antibiotic or probiotic use for 8 weeks;
- •No preoperative chemotherapy or radiation therapy prior to the examination;
- •Voluntary intravenous blood collection, gastroscopy, extraction of gastric juice and pathological biopsy.
- •Voluntary testing for H. pylori
排除标准
- •had undergone upper gastrointestinal and colon surgery;
- •Previous diagnosis of Malignant Tumors;
- •Presence of a disease or medication that affects bile acid metabolism, such as endocrine or autoimmune diseases;
- •Recent use of drugs that affect gastrointestinal motility;
- •Presence of contraindications to endoscopy;
- •pregnant and lactating women;
- •Those with mental disorders;
- •Refusal to sign the informed consent form.
结局指标
主要结局
corelation between the bile acid profile and gastric mucosa diseases
时间窗: up to 6 months
Investigators evaluate the corelation between the bile acid profile and gastric mucosa diseases according to the results of UPLC-MS/MS and pathological .
corelation between the bile acid profile and gastric microbiota in different groups
时间窗: up to 6 months
Investigators explore the cross-talk between bile acid and gastric microbiota according to the results of 16s rRNA sequencing
次要结局
未报告次要终点
研究者
Yongquan Shi
Principal Investigator, Clinical Professor
Xijing Hospital of Digestive Diseases