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临床试验/NCT04660058
NCT04660058已完成不适用

Associations Among Serum and Gastric Juice Bile Acid Profile, Bile Acid-microbiota Cross-talk in Stomach and the Development of Gastric Cancer: A Case-control Study

Xijing Hospital of Digestive Diseases1 个研究点 分布在 1 个国家目标入组 73 人开始时间: 2020年12月20日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
73
试验地点
1
主要终点
corelation between the bile acid profile and gastric mucosa diseases

研究概览

简要总结

To explore the associations among bile acid profile, bile acid-microbiota cross-talk and the development of gastric cancer, so as to better prevent the occurrence and development of gastric cancer

详细描述

This study is a case-control study. Patients, according to the pathological results, will be consecutively enrolled and divided into gastric cancer group, gastric precancerous lesions group, and chronic gastritis group. The serum and gastric juice bile acid profiles, gastric microbial composition of each group patients will be detected.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Other

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age 18 to 75 years old, gender is not limited;
  • No history of antibiotic or probiotic use for 8 weeks;
  • No preoperative chemotherapy or radiation therapy prior to the examination;
  • Voluntary intravenous blood collection, gastroscopy, extraction of gastric juice and pathological biopsy.
  • Voluntary testing for H. pylori

排除标准

  • had undergone upper gastrointestinal and colon surgery;
  • Previous diagnosis of Malignant Tumors;
  • Presence of a disease or medication that affects bile acid metabolism, such as endocrine or autoimmune diseases;
  • Recent use of drugs that affect gastrointestinal motility;
  • Presence of contraindications to endoscopy;
  • pregnant and lactating women;
  • Those with mental disorders;
  • Refusal to sign the informed consent form.

结局指标

主要结局

corelation between the bile acid profile and gastric mucosa diseases

时间窗: up to 6 months

Investigators evaluate the corelation between the bile acid profile and gastric mucosa diseases according to the results of UPLC-MS/MS and pathological .

corelation between the bile acid profile and gastric microbiota in different groups

时间窗: up to 6 months

Investigators explore the cross-talk between bile acid and gastric microbiota according to the results of 16s rRNA sequencing

次要结局

未报告次要终点

研究者

发起方
Xijing Hospital of Digestive Diseases
申办方类型
Other
责任方
Principal Investigator
主要研究者

Yongquan Shi

Principal Investigator, Clinical Professor

Xijing Hospital of Digestive Diseases

研究点 (1)

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