T-cell activation in high lipoprotein(a) patients

Completed

• Conditions: high lipoprotein(a); 10011082; Atherosclerosis; cardiovascular disease; 10003216

• Registration Number: NL-OMON49849
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

1. High lipoprotein(a) with known cardiovascular disease
2. Low lipoprotein(a) with known cardiovascular disease
3. High lipoprotein(a) without known cardiovascular disease
4. Low lipoprotein(a) without known cardiovascular disease

Exclusion Criteria

- HIV
- Chronic kidney disease
- Any condition which could possibly interfere with the conduction or outcome
of the study to the opinion of the investigator

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>We will compare the phenotype, cytokine production and epigenetic<br /><br>characteristics of T cells between patients with high and low Lp(a), with and<br /><br>without a history of cardiovascular disease. Additionally, we will determine<br /><br>the conditions under which healthy T cells are promoted to pro-inflammatory<br /><br>phenotypes and evaluate the ex vivo reversibility of this phenotype.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>