NCT00497016已完成不适用
Does Statin Therapy Reduce Sympathoexcitation in Hypertension?
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- change in central sympathetic activity
研究概览
简要总结
A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(Known) hypertension
- •stable drug therapy for at least 2 months
- •age 18-70 jaar
- •BMI 18-35 kg/m2
- •Sinusrhythm
排除标准
- •Recent cardiovascular event <6 mnd
- •Plasma Creatinin:
- •female: >120 mmol/L
- •male: >133 mmol/L
- •tricyclic antidepressants
- •alpha-1 -and/or alpha-2 blockers
- •disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)
- •Albuminuria >300 mg/dag
结局指标
主要结局
change in central sympathetic activity
次要结局
- change in cholesterol levels, renin and aldosteron
研究者
研究点 (2)
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