Antimicrobial Stewardship Reduces MDRO Isolates in Critically Ill Patients

Completed

• Conditions: Sepsis

• Registration Number: NCT02128399
• Lead Sponsor: Jianfeng Xie

Brief Summary

Antimicrobial exposure is known to reduce the selection for various drug-resistant organisms. Numerous studies have demonstrated the association between antimicrobial use and MDR bacteria detection. However, to the investigators knowledge, there is few data to support the concept that reducing antibiotic use actually leads to improvements in antibiotic susceptibilities. Moreover, antimicrobial stewardship was demonstrated to reduce MDRO and was strongly recommended in clinics. As the investigators know, antimicrobial overuse, which occurs commonly in China, induces a severe antibacterial resistance. China's Ministry of Health (MOH) has established a policy about the antimicrobial stewardship. To date, the investigators do not have published documentation the effects of this policy on multidrug-resistant organism (MDRO) in critically ill patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06
• Status Verified: 2012-07
• Primary Completion: 2013-05
• Study Completion: 2013-12
• Study First Submitted: 2014-04-22
• Study First Submitted QC: 2014-04-29
• Last Update Submitted: 2014-04-29
• Study First Posted: 2014-05-01
• Last Update Posted: 2014-05-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 978

Inclusion Criteria

• Patients hospitalized in the ICU

Exclusion Criteria

• Patients who were readmitted to the ICU during a single hospital stay

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The number of participates infection or colonization with MDRO in critically ill patients at ICU admission and discharge as a measure of effect of antimicrobial stewardship	up to 90 days	MDRO isolation from inclusion to the date of discharge of hospital, access up to 90 days