NCT01708096已完成不适用
Mechanisms Behind Antidiabetic Effects by Gastric By-pass
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Insulin sensitivity
研究概览
简要总结
The aim of the study is to develop new strategies in treatment of continuous increasing number of patients with type 2 diabetes by understanding how bariatric surgery cures or improves this condition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diabetes typ 2
- •18-70 years
- •BMI > 35 kg/m2
- •Treated with oral antidiabetic agents and/or insulin
- •laparoscopic surgery
排除标准
- •Pharmacological treatment (other then above) witch could affect glucose metabolism
- •open surgery
研究组 & 干预措施
Modifast
Active Comparator
treated with VLD Modifast 1000 kcal/day in 2 weeks before gastric by-pass,
干预措施: Modifast (Dietary Supplement)
Normal diet
Placebo Comparator
normal diet 2 weeks before gastric by-pass surgery
干预措施: Normal diet (Dietary Supplement)
结局指标
主要结局
Insulin sensitivity
时间窗: 12-18 month after gastric bypass
Insulin sensitivity measured by hyperinsulinemic normoglycemic clamp technique
次要结局
- Weight reduction(12-18 month after gastric bypass)
研究者
Anders Thorell
Assoc. Professor
Karolinska Institutet
研究点 (2)
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