Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function

Completed

• Conditions: Smoking; Obstructive Sleep Apnea

• Registration Number: NCT00957463
• Lead Sponsor: The University of Hong Kong

Brief Summary

The hypothesis of this study is that either obstructive sleep apnea (OSA) or cigarette smoking (CS) exposure would produce oxidative stress and inflammation leading to endothelial injury, and the combined exposure would be additive or synergistic.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-06
• Study First Submitted: 2009-08-10
• Study First Submitted QC: 2009-08-11
• Study First Posted: 2009-08-12
• Primary Completion: 2011-12
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-29
• Last Update Posted: 2014-12-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• No acute illness
• No hospitalization in past 4 weeks
• Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness

Exclusion Criteria

• Mentally incapacitated

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
reactive hyperemia induced peripheral arterial tone (RH-RAT) index	baseline

Secondary Outcome Measures

Name	Time	Method
circulatory metabolic and vascular inflammatory biomarkers	baseline

Trial Locations

Locations (1)

Queen Mary Hospital; 🇭🇰 Hong Kong, Hong Kong