The Study of Breast MRI Screening and Proton Magnetic Resonance Spectroscopy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 270
- 试验地点
- 1
- 主要终点
- comparison of lipid water composition and ratio of the normal breasts in women of high risk group and low risk group.
研究概览
简要总结
To delineate if the chemical composition (lipid and water) in the presumably normal breast of the high risk women is different from those of the low risk group.
详细描述
The researchers would like to investigate and compare the chemical composition in the normal breast between high risk women and general population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women without breast symptoms (without family history of breast cancer; or with at least first-degree relative of breast cancer) with negative mammography and ultrasound result in recent 3 months or contralateral normal breasts from women with newly diagnosed unilateral breast cancer
- •25-75 years old.
排除标准
- •renal function impairment
- •past history of anaphylactoid reaction to MRI contrast media (Gd-DTPA)
- •pregnant or lactating women
- •medication of HRT or oral pills in recent 6 months
- •past history of surgery of the breast (either side)
- •past history of breast cancer
- •with breast implant or silicone injection
- •past history of cardiac surgery, mechanical valve replacement, aneurismal clip, endotracheal tube or tracheostomy tube, any metallic implants.
研究组 & 干预措施
proton magnetic resonance spectroscopy
proton magnetic resonance spectroscopy for asymptomatic women breasts.
干预措施: proton magnetic resonance spectroscopy (Procedure)
结局指标
主要结局
comparison of lipid water composition and ratio of the normal breasts in women of high risk group and low risk group.
时间窗: up to 5 years ( July 2008 to June 2013)
This is a cross sectional study. And we just assess the chemical composition of normal breasts of women at a given time point, since the participants only received one time of study.
次要结局
- to investigate the association between breast density and lipid water ratio of normal breasts(up to 5 years (July 2008 to June 2013))
- to investigate the association between menopausal status and lipid water ratio of normal breasts(up to 5 years ( July 2008 to June 2013))
研究者
National Taiwan University Hospital
physician, clinical assistant professor, principal investigator of Department of Medical Imaging
National Taiwan University Hospital