Effects of Postural Adjustment on Hemodynamics in Patients Undergoing Prone Spine Surgery Under General Anesthesia

Not Applicable

Recruiting

• Conditions: Asana Adjustment
• Interventions: Behavioral: Asana adjustment

• Registration Number: NCT05749978
• Lead Sponsor: Zhuan Zhang

Brief Summary

The prone position is a special position often used for spinal surgery. As a special position of general anesthesia, after induction of general anesthesia, severe hemodynamic fluctuations often occur when the supine position is changed to the prone position, which seriously affects the patient's circulatory and respiratory functions.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-01
• Study Start: 2023-01-01
• Study First Submitted: 2023-02-18
• Study First Submitted QC: 2023-02-18
• Last Update Submitted: 2023-02-18
• Study First Posted: 2023-03-01
• Last Update Posted: 2023-03-01
• Primary Completion: 2023-10-30
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Prone spine surgery after general anesthesia is planned.
2. Age 18~85 years old.
3. ASA grade I or II.
4. BMI18.3-30kg/m2

Exclusion Criteria

1. Unstable angina or myocardial infarction, coronary heart disease, congestive heart failure, structural heart disease, arrhythmia within 6 months;
2. Increased intracranial pressure and central nervous system injury or disease;
3. Severe hypertension
4. Patients with other diseases affecting their own circulatory system.
5. Have or have a history of severe mental disorders;
6. Bleeding volume >600ml or intraoperative blood transfusion treatment.
7. Severe liver and kidney insufficiency

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Trendelenburg position	Asana adjustment	-

Primary Outcome Measures

Name	Time	Method
Changes in the level of Cardiac output	Preoperatively,5 minute after anesthesia induction,Immediately before the prone position, Immediately after the prone position,1 minute after prone position, 3 minute after prone position,10 minute after prone position,Half an hour after prone position	Cardiac output
Change in Blood pressure	Preoperatively,5 minute after anesthesia induction,Immediately before the prone position, Immediately after the prone position,1 minute after prone position, 3 minute after prone position,10 minute after prone position,Half an hour after prone position	Hemodynamics

Secondary Outcome Measures

Name	Time	Method
Vasoactive drugs	Intraoperatively	Vasoactive drug dosage
Intra-abdominal pressure level	Preoperatively,5 minute after anesthesia induction,Immediately before the prone position, Immediately after the prone position,1 minute after prone position, 3 minute after prone position,10 minute after prone position,Half an hour after prone position	Intra-abdominal pressure

Trial Locations

Locations (1)

the Affiliated Hospital of Yangzhou University, Yangzhou University; 🇨🇳 Yangzhou, Jiangsu, China