Evaluation of efficacy of injectable hyaluronic acid in reconstruction of interdental papilla
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- inter-papillary regeneration
研究概览
简要总结
This study will investigate the effect of hyaluronic acid gel injections on interdental papilla without comparing it to other treatments. The effectiveness will be evaluated over a three-month period by measuring the reduction in black triangle height using photographic analysis. Hyaluronic acid, a nonimmunogenic substance, activates cellular processes such as migration, proliferation, and gene expression. A larger sample size than previous studies will be used, with treatment indicated when the bone crest-to-contact point distance exceeds 5 mm, as recommended by Norland and Tarnow 1998. All participants will receive full-mouth scaling and polishing one week before treatment to ensure tissue healing and reduce inflammation. Local anesthesia will be applied at the mucogingival junction before hyaluronic acid injection to avoid interference with hyaluronic acid and reduce tissue punctures. A second hyaluronic acid injection will be administered after three weeks to reinforce the initial effect, based on manufacturer guidelines and previous studies. A follow-up evaluation will be conducted three months after the initial injection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)(—)
- 性别
- All
入选标准
- •Non-smoking patient.
- •Had at least one site with interdental papilla recession in the anterior region of the maxillary and mandibular jaws.
- •No active periodontal diseases and good oral hygiene.
排除标准
- •If patient have spacing or crowding between the teeth to be treated, abnormal tooth shape, systemic diseases such as diabetes mellitus, hypertension or conditions that alter the outcome of periodontal therapy.
- •Pregnant and lactating women and tobacco users excluded.
结局指标
主要结局
inter-papillary regeneration
时间窗: 3 months
次要结局
- subject perspective towards esthetic zone(3 months)
