跳至主要内容
临床试验/CTRI/2025/04/085597
CTRI/2025/04/085597招募中不适用

Evaluation of efficacy of injectable hyaluronic acid in reconstruction of interdental papilla

Parveen Dahiya1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2025年5月15日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
15
试验地点
1
主要终点
inter-papillary regeneration

研究概览

简要总结

This study will investigate the effect of hyaluronic acid gel injections on interdental papilla without comparing it to other treatments. The effectiveness will be evaluated over a three-month period by measuring the reduction in black triangle height using photographic analysis. Hyaluronic acid, a nonimmunogenic substance, activates cellular processes such as migration, proliferation, and gene expression. A larger sample size than previous studies will be used, with treatment indicated when the bone crest-to-contact point distance exceeds 5 mm, as recommended by Norland and Tarnow 1998. All participants will receive full-mouth scaling and polishing one week before treatment to ensure tissue healing and reduce inflammation. Local anesthesia will be applied at the mucogingival junction before hyaluronic acid  injection to avoid interference with hyaluronic acid and reduce tissue punctures. A second hyaluronic acid injection will be administered after three weeks to reinforce the initial effect, based on manufacturer guidelines and previous studies. A follow-up evaluation will be conducted three months after the initial injection.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
Participant and Investigator Blinded

入排标准

年龄范围
18.00 Year(s) 至 45.00 Year(s)(—)
性别
All

入选标准

  • Non-smoking patient.
  • Had at least one site with interdental papilla recession in the anterior region of the maxillary and mandibular jaws.
  • No active periodontal diseases and good oral hygiene.

排除标准

  • If patient have spacing or crowding between the teeth to be treated, abnormal tooth shape, systemic diseases such as diabetes mellitus, hypertension or conditions that alter the outcome of periodontal therapy.
  • Pregnant and lactating women and tobacco users excluded.

结局指标

主要结局

inter-papillary regeneration

时间窗: 3 months

次要结局

  • subject perspective towards esthetic zone(3 months)

研究者

发起方
Parveen Dahiya
申办方类型
Other [self]

研究点 (1)

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