Multimodal approach in long term longitudinal in-vivo monitoring the clinical outcomes of graft maturation of injected matrix-assisted autologous chondrocyte transplantation in individual patients – clinical, morphological MRI and biochemical quantitative T2-mapping, T1rho and diffusion-weighted-imaging.
Recruiting
- Conditions
- M23.99M22.4Chondromalacia patellae
- Registration Number
- DRKS00015471
- Lead Sponsor
- Klinikum der Universität München, Campus Großhadern
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
minimum age 18 years, maximum age 60 years. Isolated cartilage defect of at least 2 cm² size. ACTinject treatment of the knee at least 3 month previously. Signed informed consent form.
Exclusion Criteria
More then 2 cartilage defects. (Osteo-)arthritis. Instability of the knee joint. Incomplete follow-up data. General contraindications for MRI.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Aim of this study is the explorative comparison of patients after ACTinject treatment for a duration of 36 months concerning clinical as well as MRI-parameters.
- Secondary Outcome Measures
Name Time Method Temporal course of MRI-parameters in line with graft maturation.<br>Correlation between clinical Parameters an MRI-parameters during different timepoints (3, 6, 12, 24 and 36 months).