International Registry of Congenital Portosystemic Shunt (IRCPSS)
- Conditions
- Congenital Portosystemic ShuntCPSS (Congenital Portosystemic Shunt)
- Interventions
- Procedure: Shunt Closure
- Registration Number
- NCT06041906
- Lead Sponsor
- Prof. Valérie Mc Lin
- Brief Summary
Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and severity of associated complications.
CPSS is venous anomaly in which blood coming from the intestines only partially passes through the liver.
This leads to the accumulation of potentially toxic factors that cause systemic effects.
Complications vary among the individuals, and currently, it is challenging to predict which individuals will develop severe complications.
The IRCPSS registry is established with the aim of centralizing detailed clinical follow-up and biological information from participants around the world who suffer from Congenital Portosystemic Shunt (CPSS). A multidisciplinary consortium of experts is collaborating to enhance our understanding of the prevalence, natural history, individual risks, and physiopathology of the disease through the IRCPSS registry.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 500
Individual with CPSS
Secondary shunt without evidence of congenital shunt
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Neonate, Children, Adult with CPSS Shunt Closure -
- Primary Outcome Measures
Name Time Method Number of patients developing one or more complications 5; 10; 20 years Numbers of patients with spontaneous shunt closure 3; 6; 12; 24 months Number of patients undergoing preemptive closure 6; 12; 24 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (26)
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States
Lurie Children's Hospital
🇺🇸Chicago, Illinois, United States
Royal Children's Hospital Melbourne
🇦🇺Parkville, Victoria, Australia
Universitary Clinics Saint-Luc, UCL
🇧🇪Brussels, Belgium
The Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada
Beaujon University Hospital
🇫🇷Clichy, France
Hôpital Bicêtre-Hôpitaux Universitaires Paris-Sud- Assistance Publique Hôpitaux de Paris.
🇫🇷Le Kremlin-Bicêtre, France
Hôpital Necker
🇫🇷Paris, France
Hannover Medical School
🇩🇪Hannover, Germany
Haunersche Kinderklinik - LMU Munich
🇩🇪Munich, Germany
Scroll for more (16 remaining)Yale University School of Medicine🇺🇸New Haven, Connecticut, United States