Effect of Acetaminophen and Dexamethasone on agitation in tonsillectomy childre
Phase 3
Recruiting
- Conditions
- Tonsil's inflammation.Tonsil, unspecified
- Registration Number
- IRCT20171016036817N1
- Lead Sponsor
- Zahedan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 140
Inclusion Criteria
Parents are satisfied with entering the study
All children aged 2 to 7 years undergoing tonsillectomy
Exclusion Criteria
Those who have taken previous medications (all previous medications should be removed within 2 hours before the surgery)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Agitation. Timepoint: Prior to admission, pain is measured by face scale and children's agitation will measured by the Richmond Agitation Sedation Score. The two cases are also measured after admission and receiving drugs in the PICU, as well as 10, 20, and 30 minutes after extubation of the tube tract. (0: vigilant and calm, 1: restless, 2: disturbed, 3: very disturbed and 4: controversy and fights). Method of measurement: pain is measured by face scale and children's agitation will measured by the Richmond Agitation Sedation Score.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie acetaminophen and dexamethasone's anti-agitation effects in pediatric tonsillectomy patients?
How does the combination of acetaminophen and dexamethasone compare to standard-of-care analgesics for post-tonsillectomy agitation in children?
Are there specific biomarkers that predict response to corticosteroid and analgesic co-administration in postoperative pediatric populations?
What adverse event profiles are associated with dexamethasone use in combination with acetaminophen for pediatric tonsillectomy recovery?
What alternative combination therapies for post-tonsillectomy agitation have been evaluated in phase III trials sponsored by Zahedan University of Medical Sciences?