NCT00166322已完成不适用
Dopaminergic Neurotransmission in Schizophrenia, Patients at Risk and Healthy Subjects
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 4
- 主要终点
- dopamine receptor availability
研究概览
简要总结
This study is an investigation of the dopaminergic neurotransmission in patients with schizophrenia, patients at risk for the development of schizophrenia, and healthy controls using an iodobenzamide-single photon emission computed tomography (IBZM-SPECT) imaging technique under amphetamine challenge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of schizophrenia (currently unmedicated)
- •Subjects at risk for the development of schizophrenia (prodromal symptoms)
- •Healthy subjects
- •Written informed consent
排除标准
- •Neurological or severe somatic disorders
- •Women during pregnancy or lactation
- •Occupational exposition to radiation > 15mSv
- •Medication known to interfere with IBZM
- •Contraindications for the use of amphetamine challenge
结局指标
主要结局
dopamine receptor availability
时间窗: cross-sectional
次要结局
未报告次要终点
研究者
研究点 (4)
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