Comparative evaluation of effect of IPRF and Piezocision on rate of orthodontic tooth movement and RANKL and OPG levels in GCF An in vivo study.
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- GCF samples will be collected from buccal and distobuccal sides of canine of experimental side and the control side, in both, 1-PRF and piezocision group.
研究概览
简要总结
We are doing this study to compare and evaluate the effect of IPRF and Piezocision on the rate of orthodontic tooth movement during en-masse retraction and levels of RANKL and OPG in gingival crevicular fluid ( GCF).
OBJECTIVES OF THE STUDY WILL BE :
l)To clinically evaluate the effect of 1-PRF on rate of Orthodontic Tooth movement during en-masse retraction.
2)To clinically evaluate the effect of piezocision technique on rate of orthodontic tooth movement during en-masse retraction.
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To compare the effects of 1-PRF and piezocision on rate of orthodontic tooth movement during en-masse retraction.
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To assess change in levels of RANKL and OPG in gingival crevicular fluid (GCF) during orthodontic tooth movement with IPRF and piezocision.(during en-masse retraction).
This will help us to evaluate efficacy of procedures like Injectable platelet rich fibrin and piezocision in making tooth movement faster in decreasing treatment time during orthodontic treatment .
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Aged 18 years or above.
- •Patient requiring maxillary first Premolar extraction.
- •Angle’s class I/ class II molar relationship.
- •No history of orthodontic treatment.
- •No systemic disease.
- •No periodontal disease.
- •Good oral hygiene.
排除标准
- •Patients with Systemic diseases -Patients taking medication that can interfere with orthodontic treatment.
- •Poor oral hygiene. -Periodontally compromised patients. -Patients with parafunctional habits -Angles’s class III molar relationship -Extraction other than first premolar extraction in the maxillary arch.
结局指标
主要结局
GCF samples will be collected from buccal and distobuccal sides of canine of experimental side and the control side, in both, 1-PRF and piezocision group.
时间窗: baseline | 2 weeks | 4 weeks | 6 weeks
次要结局
未报告次要终点
研究者
Dr Ratika Sawhney
Inderprastha Dental College and Hospital