Effects of a Diet High in Protein and Energy in Combination With Physical Activity for the Improvement of Coughing Capacity in COPD Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Improvement of coughing capacity of COPD patients
研究概览
简要总结
Chronic Obstructive Lung Disease (COPD) is one of the leading death causes worldwide. COPD is a disease that is characterized by chronic inflammation which leads to irreversible damage of airways and lung tissue. This intervention investigates the effects of a diet high in protein and energy for the improvement of coughing capacity and lung function of COPD patients. The patients will be recruited as part of a lung rehabilitating programme which takes place in Bispebjerg and Hvidovre Hospital. The intervention group receives individual nutritional guidelines whereas the control group continues their usual diet. Blood tests will be performed at baseline and the end of the study. Other anthropometric measures include spirometry for lung function, hand grip strength and fat free mass to assess muscle waisting.
详细描述
40 patients with COPD randomized to diet with protein 1.3 g/kg/day or habitual intake:
Primary endpoint (before-after): Leicester Cough Questionnaire Secondary endpoints: ADL-score, no. daily cough periods, development in FEV1 and FVC, hand-grib-strenght, use of respiratory medications, smoking, appetite, admissions to hospital, antibiotics and/or steroids, oxygen saturation, FFM (BIA), Coughs tests in spirometer and peak-flow-meter
Study period: 2 months
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with COPD
- •Participating in ongoing lung rehabilitating programme at Hvidovre and Bispebjerg Hospital
- •over 18 years
排除标准
- •Plasma creatinin over 200 mikrog/l
- •unable to read or speak danish
研究组 & 干预措施
Intervention group
1.3 g protein per kg bodyweight per day for 8 weeks
干预措施: High protein and energy diet (Dietary Supplement)
Kontrol group
habitual diet
干预措施: Habitual Diet (Other)
结局指标
主要结局
Improvement of coughing capacity of COPD patients
时间窗: 8 weeks
Measured by a validated danish version of Leicester Cough Questionnaire (1-7 points)
次要结局
- Weight change(8 weeks)
- Oxygen saturation before and after treatment(8 weeks)
研究者
Jens Rikardt Andersen
Associate Professor
University of Copenhagen