Impact of a cardiac rehabilitation program versus coronary revascularization in patients with stable coronary artery disease

Recruiting

• Conditions: chestpain; Stable angina pectoris; 10011082

• Registration Number: NL-OMON52330
• Lead Sponsor: Maxima medisch centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 216

Inclusion Criteria

- Stable angina pectoris with residual anginal symptoms after optimal medical
therapy
- Established ischemia (assessed by SPECT, PET, stress ultrasound, CMR, or
cycle ergometry)
- Access to a personal computer, laptop or tablet with internet connectivity at
home
- Access to a mobile phone with short message service (SMS) functionality to
login to the web application with two-factor authentication

Exclusion Criteria

An echocardiography and coronary angiography (usual care group) or coronary
computed tomography (CT)-angiography (cardiac rehabilitation group) will be
performed at baseline to exclude high-risk patients with a reduced left
ventricular function (i.e. left ventricular ejection fraction <35%) or left
main coronary artery disease. For these patients previous work revealed the
potential prognostic benefit of revascularization, in terms of mortality, also
supported by latest guidelines on myocardial revascularization with a class 1A
indication for revascularization.

Other exclusion criteria include:
1. PCI or CABG in the past year
2. Acute coronary syndrome in past 2 months
3. Angina symptoms at rest or rapidly progressive (i.e. unstable angina)
4. Ischemic threshold <50 watts
5. New-York Heart Association class III-IV heart failure symptoms
6. Advanced chronic kidney failure (i.e. estimated Glomerular Filtration rate
<30ml/min)
7. Severe ventricular arrhythmia or exercise-induced arrythmia at baseline
testing
8. A comorbidity precluding exercise training (e.g. orthopaedic, neurological
or cognitive conditions) or other contra-indications for exercise training.

Study & Design

• Study Type: Interventional
• Study Design: Not specified