JPRN-UMIN000005654
Recruiting
Phase 2
The Efficacy and Feasibility Study of Neoadjuvant Chemotherapy without Radiotherapy for Locally Advanced Rectal Cancer (Est-Neo) - The Efficacy and Feasibility Study of Neoadjuvant Chemotherapy without Radiotherapy for Locally Advanced Rectal Cancer
Gastro-intestinal Sugery Division, Kyoto University Hospital0 sites55 target enrollmentJune 1, 2011
ConditionsRectal Cancer
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Rectal Cancer
- Sponsor
- Gastro-intestinal Sugery Division, Kyoto University Hospital
- Enrollment
- 55
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •\# Distant metastases \# Cerebrovascular disease (CVD) with paralytic symptoms or prior CVD within one year. \# Symptomatic or actively treated cardiac disorders. Or prior cardiac disorder within one year. \# Cancerous fluid on diagnostic imaging. \# Prior chemotherapy or pelvic irradiation for malignancy. \# Other cancer diagnosis within the past 5 years (including colorectal cancer). \# Interstitial pneumonia or fibroid lung. \# Uncontrolled infection. \# Current symptoms of neuropathy, defined as \>\= grade 2 neurosensory or neuromotor toxicity. \# Ileus (cases with diverting stoma are eligible). \# Uncontrolled diarrhea. \# Pregnant, nursing or no intention to contraception. \# Contraindication for the administration of bevacitumab (In the cases of KRAS mutant\-type) \# Those considered inappropriate for participation in this trial.
Outcomes
Primary Outcomes
Not specified
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