Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain

Completed

• Conditions: Left Ventricular Dysfunction; Spinal Anesthetics Causing Adverse Effects in Therapeutic Use; Global Cardiac Wall Motion Dysfunction

• Registration Number: NCT05650008
• Lead Sponsor: Milton S. Hershey Medical Center

Brief Summary

The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-12-06
• Study First Submitted QC: 2022-12-06
• Study First Posted: 2022-12-14
• Study Start: 2023-02-01
• Primary Completion: 2023-10-10
• Study Completion: 2023-10-10
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-21
• Last Update Posted: 2023-11-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Adult patients undergoing elective knee and hip replacements under spinal anesthesia

Exclusion Criteria

• Patients who do not wish to consent
• Patients with contraindications to TTE
• Patients with reduced left ventricular systolic function as defined by LV ejection fraction < 50% on pre-operative echocardiography
• Patients with body mass index greater than 40
• Non-English-speaking subjects
• Cognitively impaired adults

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Left Ventricular Global Longitudinal Strain	5 minutes

Secondary Outcome Measures

Name	Time	Method
Left Ventricular Ejection Fraction	5 minutes

Trial Locations

Locations (1)

Milton S. Hershey Medical Center; 🇺🇸 Hershey, Pennsylvania, United States