Dietary salt and blood vessel functio

Not Applicable

Recruiting

• Conditions: Endothelial function; Cardiovascular - Normal development and function of the cardiovascular system; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12611000583943
• Lead Sponsor: Commonwealth Scientific and Industrial Research Organisation (CSIRO): Food and Nutritional Science

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-06-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Male or female aged 18-70
BMI <28kg/m2 and > 18.5 kg/m2
Systolic blood pressure <130mmHg
Diastolic blood pressure <90mmHg
Weight stable over the past 6 months

Exclusion Criteria

-Know metabolic disease such as liver or kidney disease
-Treated hypertension
-Previous clinical cardiovascular disease
-Use of non-steroidal anti-inflammatory drugs, folate supplementation or systemic steroids
-Significant weight loss (>5% body weight) in preceding 6 months
-Unable to comprehend study protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in plasma ADH, ANP, osmolality and osmolarity[Blood biomarkers are measured at each of the following time points: Baseline (immediately before test meal consumption); post meal consumption at 30minutes; 60minutes; 90minutes; 120minutes];Change in plasma electrolytes. Blood samples will be analysed by a certified commercial laboratory.<br>Change in plasma nitrate/nitrite will be measured using a commercially available enzyme-linked immunoassay (ELISA) kit.[Blood biomarkers are measured at each of the following time points: Baseline (immediately before test meal consumption); post meal consumption at 30minutes; 60minutes; 90minutes; 120minutes]

Secondary Outcome Measures

Name	Time	Method
Thirst will be measured using a visual analogue scale[Thirst will be measured at each of the following time points: Baseline (immediately before test meal consumption); post meal consumption at 30minutes; 60minutes; 90minutes; 120minutes];Change in vascular function as measured by Augmentation Index (AIx)[Augmentation index is measured at each of the following time points: Baseline (immediately before test meal consumption); post meal consumption at 30minutes; 60minutes; 90minutes; 120minutes]