Effects of Alcohol on Simulated Driving

Not Applicable

Completed

• Conditions: Alcoholism
• Interventions: Drug: alcohol

• Registration Number: NCT00477984
• Lead Sponsor: Utrecht Institute for Pharmaceutical Sciences

Brief Summary

Previous studies have shown that alcohol significantly impairs driving performance. Acute alcohol administration also has a detrimental effect on secondary task performance during dual-tasks. The present study will investigate the effects of five different dosages of ethanol (0,0.2, 0,5, 0,8 and 1,0 % BAC) on performance in a driving simulator. Steering performance and brain activity will be recorded in both single- and dual-task conditions.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-05
• Study First Submitted: 2007-05-23
• Study First Submitted QC: 2007-05-23
• Study First Posted: 2007-05-24
• Primary Completion: 2008-03
• Study Completion: 2008-03
• Status Verified: 2008-04
• Last Update Submitted: 2008-04-11
• Last Update Posted: 2008-04-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• He/she is aged between 21-50
• Written informed consent
• Right-handed
• Normal static binocular acuity, corrected or uncorrected
• Normal hearing
• Social Drinker (average of 7 to 21 alcoholic drinks per week)
• Possession of a drivers license
• Be considered as reliable and mentally capable of adhering to the protocol.

Exclusion Criteria

• Current drug use (positive urine drug screen on the presence of amphetamines (including MDMA), barbiturates, cannabinoids, benzodiazepines, cocaine, and opiates)
• Positive urine pregnancy drug screen in women
• Use of psychoactive medication
• Positive alcohol breath test
• Prior enrolment in the same study
• Physical or mental illness
• Excessive alcohol use (>21 alcoholic drinks per week)
• Excessive smoking (more than 10 cigarettes per day)
• Intake of caffeine-containing beverages over 5 glasses per day

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
A	alcohol	alcohol and placebo

Primary Outcome Measures

Name	Time	Method
Primary parameter of the steering simulator is the standard deviation of the car from the center of the road (steering error).	5 testdays

Secondary Outcome Measures

Name	Time	Method
Reaction speed after hearing the deviant target tone. Brain activity: ERPs of interest are the mismatch negativity (MMN), P3a, P3b, and reorienting negativity (RON)	5 testdays

Trial Locations

Locations (1)

Utrecht Institute for Pharmaceutical Sciences; 🇳🇱 Utrecht, Netherlands