ERASURE-Trial: Early autologous blood pleurodesis for postoperative air leaks - A randomized, controlled trial comparing prophylactic autologous blood pleurodesis versus standard watch and wait treatment for postoperative air leaks following thoracoscopic (VATS) anatomic lung resections

Not Applicable

Recruiting

• Conditions: C34.0; C78.0; Main bronchus; Secondary malignant neoplasm of lung

• Registration Number: DRKS00030810
• Lead Sponsor: niversitätsmedizin der Johannes Gutenberg-Universität Mainz

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-12-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. Elective, thoracoscopic, anatomic lung resection (lobectomy or segmentectomy)
2. Air leak > 100ml/min within 6 h prior to the morning round of the second postoperative day

Exclusion Criteria

1. Patients undergoing an open lobectomy
2. Patients undergoing complex lobectomies (bronchoplastic reconstructions etc.)
3. Patients requiring invasive or positive pressure non-invasive ventilation except in the first 6 hours following the operation
4. Patients undergoing re-operation during the same hospital admission
5. Suspected or proven bronchial stump leakage
6. Intraoperative use of sealants, pleural tents or talcum

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to drain removal measured in full days

Secondary Outcome Measures

Name	Time	Method
1.Time to cessation of the air leak (calculated in postoperative hours)<br>2.Length of postoperative stay measured in full days<br>3.Rate of (redo) interventions due to persistent air leaks<br>4.Rate of pleural empyemas