Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism

Not Applicable

Completed

• Conditions: Metabolic Syndrome
• Interventions: Dietary Supplement: amino-acid + fructose; Dietary Supplement: Fructose+maltodextrin placebo

• Registration Number: NCT01119989
• Lead Sponsor: University of Lausanne

Brief Summary

10 healthy male volunteers will be studied after

* a 6 day weight maintenance, balanced diet

* a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day

* a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained

* intrahepatic lipids (1H-MRS)

* metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics)

This is a randomized, double blinded study

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05
• Study First Submitted: 2010-05-06
• Study First Submitted QC: 2010-05-07
• Study First Posted: 2010-05-10
• Primary Completion: 2011-03
• Study Completion: 2011-12
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-01
• Last Update Posted: 2018-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 9

Inclusion Criteria

• age 18-30 years
• sex: males
• BMI between 19 and 25 kg/m2
• less than 3 30min- exercise session/week

Exclusion Criteria

• smokers
• alcohol consumption more than 50g/week
• consumption of drugs
• history of diabetes in first degree relatives
• presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication to NMR

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
weight maintenance diet + fructose and amino-acid	amino-acid + fructose	-
weight maintenance + fructose	Fructose+maltodextrin placebo	-

Primary Outcome Measures

Name	Time	Method
intrahepatic lipids	after 6 days on each controlled diet

Secondary Outcome Measures

Name	Time	Method
13C palmitate synthesis	after 6 days on each controlled diet

Trial Locations

Locations (1)

Centre Hospitalier Universitaire Vaudois; 🇨🇭 Lausanne, VD, Switzerland