The effects of high molecular weight sodium hyaluronate on JKOM score and urine CTX-2 concentration -A randomized comparative clinical study with loxoprofen as a control drug
- Conditions
- Osteoarthrities
- Registration Number
- JPRN-UMIN000001026
- Lead Sponsor
- Research Group of Cartilage Metabolism
- Brief Summary
The early efficacy of IA-HA was not inferior to that of NSAIDs, and the safety of early-phase of IA-HA was superior to that of NSAIDs for patients with knee OA.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 300
Not provided
;Taken glucocorticoids (intra-articular injection, oral use, external use) within previous 4weeks ;Taken NSAIDs (oral, suppository, external) within previous 2weeks ;K-L grade of contralateral knee is 4 ;Secondary OA of the knee (eg. traumatic OA of the knee) ;Patellofemoral OA (K-L grade of more than 3) ;Moderate OA other than knee ;Rheumatoid arthritis ;Having history of total knee replacement or total hip replacement ;Having history of anaphylactoid reaction to sodium hyaluronan or loxoprofene ;Peptic ulcer ;Abnormal dysemia, abnormal hepatic function, abnormal kidney function, abnormal heart function ;Aspirin-induced asthma or its history ;.Inappropriate patients from the doctor's viewpoint
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of JKOM score from baseline.
- Secondary Outcome Measures
Name Time Method