Sublingual vs Vaginal Misoprostol for Termination of First Trimesteric Missed Abortion
试验速览
- 阶段
- 早期 1 期
- 入组人数
- 288
- 主要终点
- The occurance of complete abortion within 24 hours with Misoprostol drug
研究概览
简要总结
Efficacy of sublingual versus vaginal misoprostol in termination of first trimester missed abortion
详细描述
study will be made on female patients with first trimester missed abortion confirmed by ultrasound . Participants will be divided into 2 groups one group (A) will receive sublingual Misoprostol and the other group(B) will receive vaginal Misoprostol as a 800 micro grams every 4 hours in both groups up to five doses the aim of the study is to compare efficay of sublingual and vaginal Misoprostol in complete termination of first trimester missed abortion and which route is the best will less side effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women with an ultrasound diagnosis of missed abortion < 13 weeks gestation without any clinical criteria of Inevitable abortion.
排除标准
- •Patients refused the medical treatment.
- •Patients have contraindications of the drug (Misoprostol).
- •Missed abortion associated with any signs of sepsis
研究组 & 干预措施
Sublingual Misoprostol for termination of first trimester missed abortion
Patients diagnosed as first trimester missed abortion will receive sublingual Misoprostol 800 micrograms every 4 hours up to five doses
干预措施: Misoprostol Pill (Drug)
Vaginal Misoprostol for termination of first trimester missed abortion
Patients diagnosed as first trimester missed abortion will receive vaginal Misoprostol 800 micrograms every 4 hours up to five doses
干预措施: Misoprostol Pill (Drug)
结局指标
主要结局
The occurance of complete abortion within 24 hours with Misoprostol drug
时间窗: Within 24 hours
Efficacy of sublingual and vaginal Misoprostol in complete termination of first trimester missed abortion
Which route is the best and less side effects in complete termination of first trimester missed abortion by Misoprostol drug
时间窗: within 24 hours
Vaginal versus sublingual route of administration of Misoprostol for complete termination of first trimester missed abortion
次要结局
未报告次要终点
研究者
Ahmed Mahmoud Emam Ahmed
Resident in obstetrics and gynecology
Cairo University