The Characteristics of Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Carbon Monoxide Poisoning
- Sponsor
- The First Hospital of Jilin University
- Enrollment
- 1250
- Locations
- 1
- Primary Endpoint
- Changes of Mini-mental State Examination (MMSE) score at 6 weeks
- Status
- Not yet recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to access the clinical characteristics and risk factors for neurological sequelae after acute carbon monoxide poisoning.
Detailed Description
After being informed about the study and potential risks, patients meet the inclusion criteria would be given informed consent and entry the study. The data will be collected according to self-designed questionnaire, including :1) The baseline characteristics: would be recorded 6 hours after patients presentation;2) Patients' self evaluation for discomfort symptoms: would be recorded at day 0, week 1, 3 and 6, month 6 and 12；3) Neurological function: would be recorded at day 0, week 6, month 6 and 12.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients present within 12 hours after acute carbon monoxide poisoning;
- •age older than 16 years.
Exclusion Criteria
- •pregnant women；
- •patients receive oxygen therapy before presentation;
- •have history of acute carbon monoxide poisoning within 1 year;
- •have been diagnosed any of the following disease: Parkinson disease; cognitive disorder, psychiatric disorders, sequelae of cerebral infarction or hemorrhage, chronic kidney disease and receive hemodialysis, congestive heart failure ( NYHA class III-IV)
Outcomes
Primary Outcomes
Changes of Mini-mental State Examination (MMSE) score at 6 weeks
Time Frame: Changes of score from baseline to 6 weeks
Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Hamilton Depression Scale(HAMD) score at 6 weeks
Time Frame: Changes of score from baseline to 6 weeks
Score ranges from 0 to 54, a higher score means a worse outcome.
Changes of Hamilton Depression Scale(HAMD) score at 12 months
Time Frame: Changes of score from baseline to 12 months
Score ranges from 0 to 54, a higher score means a worse outcome.
Changes of self-evaluation of discomfort symptoms scale at 1 week
Time Frame: Changes of score from baseline to 1 week
This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Changes of Mini-mental State Examination (MMSE) score at 6 months
Time Frame: Changes of score from baseline to 6 months
Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Mini-mental State Examination (MMSE) score at 12 months
Time Frame: Changes of score from baseline to 12 months
Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Montreal cognitive assessment (MoCA）score at 6 weeks
Time Frame: Changes of score from baseline to 6 weeks
Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Hamilton Anxiety Scale (HAMA) score at 6 weeks
Time Frame: Changes of score from baseline to 6 weeks
Score ranges from 0 to 56, a higher score means a worse outcome.
Changes of Montreal cognitive assessment (MoCA）score at 6 months
Time Frame: Changes of score from baseline to 6 months
Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Montreal cognitive assessment (MoCA）score at 12 months
Time Frame: Changes of score from baseline to 12 months
Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Hamilton Depression Scale(HAMD) score at 6 months
Time Frame: Changes of score from baseline to 6 months
Score ranges from 0 to 54, a higher score means a worse outcome.
Changes of Hamilton Anxiety Scale (HAMA) score at 6 months
Time Frame: Changes of score from baseline to 6 months
Score ranges from 0 to 56, a higher score means a worse outcome.
Changes of Hamilton Anxiety Scale (HAMA) score at 12 months
Time Frame: Changes of score from baseline to 12 months
Score ranges from 0 to 56, a higher score means a worse outcome.
Changes of Activity of Daily Living (ADL) score at 6 weeks
Time Frame: Changes of score from baseline to 6 weeks
Score ranges from 0 to 80, a higher score means a worse outcome.
Changes of Activity of Daily Living (ADL) score at 6 months
Time Frame: Changes of score from baseline to 6 months
Score ranges from 0 to 80, a higher score means a worse outcome.
Changes of Activity of Daily Living (ADL) score at 12 months
Time Frame: Changes of score from baseline to 12 months
Score ranges from 0 to 80, a higher score means a worse outcome.
Changes of self-evaluation of discomfort symptoms scale at 6 weeks
Time Frame: Changes of score from baseline to 6 weeks
This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Changes of self-evaluation of discomfort symptoms scale at 3 weeks
Time Frame: Changes of score from baseline to 3 weeks
This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Changes of self-evaluation of discomfort symptoms scale at 6 months
Time Frame: Changes of score from baseline to 6 months
This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Changes of self-evaluation of discomfort symptoms scale at 12 months
Time Frame: Changes of score from baseline to 12 months
This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Secondary Outcomes
- Rates of cardiovascular and cerebrovascular events(through study completion, an average of 1 year)
- Rates of accidental injury(through study completion, an average of 1 year)