Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex
- Conditions
- Premature Ventricular Contraction
- Registration Number
- NCT03447002
- Lead Sponsor
- TC Erciyes University
- Brief Summary
Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.
- Detailed Description
Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- PVC's rate is more than % 5 in 24 hours rhythm recording
- ischemic heart disease
- hyperthyroidism
- patients with low ejection fraction
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method metanephrine and normetanephrine levels about 10 months metanephrine and normetanephrine levels asociated premature ventricular complex frequents
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Erciyes university Yilmaz- mehmet öztaşkın heart hospital
🇹🇷Kayseri, Turkey