A trial looking at quality of life in the treatment of patients with malignant pleural effusio

Not Applicable

Completed

• Conditions: Topic: Cancer; Subtopic: Lung Cancer; Disease: Lung (non-small cell); Cancer; Lung cancer

• Registration Number: ISRCTN15503522
• Lead Sponsor: Guy's & St Thomas' NHS Foundation Trust

Brief Summary

2016 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/27798020 protocol 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37996243/ (added 24/11/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-09-30
• Study Completion: 2020-01-27
• Last Update Posted: 4 December 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 142

Inclusion Criteria

1. Age 18 years or over
2. Diagnosis of malignant pleural effusion
3. WHO performance status 2 or less unless performance status is impaired by presence of effusion and likely to significantly improve with drainage
4. Expected survival greater than 3 months

Exclusion Criteria

1. Aged less than 18 years old
2. Pregnant or lactating
3. Known allergy to Talc or Lignocaine
4. Lack of symptomatic relief from effusion drainage
5. At least twice weekly drainage cannot be undertaken
6. Lymphoma or small cell carcinoma except*:
6.1. Failure of chemotherapy
6.2. Deemed for palliative management
7. Non malignant effusions
8. Loculated pleural effusion
9. Unable to provide written informed consent to trial participation

*Lymphoma and small cell carcinoma are particularly sensitive to treatment with chemotherapeutic agents. If patients have undergone chemotherapy with no treatment response or deemed not for chemotherapy and for palliative management then they will be suitable for inclusion in the study. Liason with the patient’s oncologist or MDT discussion will be required to ascertain this.

Study & Design

• Study Type: Interventional
• Study Design: Not specified