Evaluation of biomarkers of acute kidney injury (AKI) in the ICU population.
- Conditions
- acute kidney injury
- Registration Number
- JPRN-UMIN000004503
- Lead Sponsor
- Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Medicine and Clinical Science
- Brief Summary
The urinary levels of prostaglandin E2 (PGE2), PGI2 metabolite (2,3-dinor-6-OXO-PGF1 alfa), thromboxane A2 (TXA2) metabolite (11-dehydro-TXB2) were determined. Of the 93 patients, 24 developed AKI (AKIN criteria). Overall, the ratio of the level of serum Cr on Day 1 after ICU admission to that observed at baseline positively correlated with the urinary 2,3-dinor-6-OXO-PGF1alfa /Cr (r = 0.57, p < 0.0001) and 11-dehydro-TXB2/Cr (r = 0.47, p < 0.0001) ratios. In 16 cases of de novo AKI, the urinary 2,3-dinor-6-OXO-PGF1 alfa /Cr and 11-dehydro-TXB2/Cr values were significantly elevated compared with that observed in the non-AKI group. The urinary 2,3-dinor-6-OXO-PGF1 alfa /Cr ratio exhibited the best diagnostic and predictive performance among the prostanoid metabolites according to the receiver operating characteristic (ROC) analysis [ROC-area under the curve (AUC): 0.75
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 200
Not provided
The patients already performing renal replacement therapy by end-stage renal disease. The patients that informed consent was obtained. Minority (under 20 years old) The patients that was discharged ICU after entering ICU for 24 hours.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method