Beyond Platelet Indices, WBC-to-MPV Ratio in Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) Correlate With Short-Term Rather Than In-Hospital Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- White blood cell count to mean platelet volume ratio (WMR)
研究概览
简要总结
This study aims to evaluate the role of platelet indices and the [White blood cell (WBC) /mean platelet volume (MPV)] ratio in correlation with angiographic profiles of patients diagnosed with myocardial infarction with non-obstructive coronary arteries (MINOCA) to assess their predictive value for short-term clinical outcomes.
详细描述
Globally, ischemic heart disease remains a significant cause of death, and its prevalence constantly increases. Around 5-15% of acute myocardial infarction (AMI) patients show nonobstructive (<50% stenosis) coronary arteries, named myocardial infarction with nonobstructive coronary arteries (MINOCA).
There are two main phases of inflammation during myocardial infarction: the inflammatory phase and the proliferative phase. The white blood cell (WBC) count and its subtypes have been investigated as potential predictors of cardiovascular outcomes in patients with coronary artery disease (CAD), serving as inflammatory markers.
The mean platelet volume (MPV) is determined in the progenitor cell, the bone marrow megakaryocyte. The platelet volume is found to be associated with cytokines (thrombopoietin, interleukin-6, and interleukin-3) that regulate megakaryocyte ploidy and platelet number and result in the production of larger platelets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old.
- •Both sexes.
- •Patients with acute myocardial infarction (AMI). Myocardial infarction with nonobstructive coronary arteries (MINOCA) is diagnosed if a patient fulfilled the AMI criteria in the absence of obstructive coronary arteries (type I: <50% stenosis; or type II: no stenosis) as recommended by the recent American Heart Association statement that introduces an updated definition incorporating the 4th universal MI definition, which by agreement excludes Takotsubo syndrome and myocarditis from the eventual diagnosis of MINOCA.
排除标准
- •Previous history of MI or coronary revascularization (PCI or bypass surgery) with acute/chronic infection.
- •Autoimmune diseases.
- •Systemic inflammatory disease.
- •Patients on treatment therapy which critically affects inflammatory cell count.
- •Patients with malignancy.
- •Chronic kidney disease.
- •Severe liver disease.
- •Severe anemia.
- •Fever (>38°C).
研究组 & 干预措施
Study group
Myocardial infarction with nonobstructive coronary arteries (MINOCA) patients
干预措施: Coronary Angiography (Other)
Study group
Myocardial infarction with nonobstructive coronary arteries (MINOCA) patients
干预措施: SYNTAX Score (Other)
Control group
Healthy control individual.
干预措施: Coronary Angiography (Other)
Control group
Healthy control individual.
干预措施: SYNTAX Score (Other)
结局指标
主要结局
White blood cell count to mean platelet volume ratio (WMR)
时间窗: Within 6 hours of symptom onset
White blood cell count to mean platelet volume ratio (WMR) will be recorded.
次要结局
- Incidence of major adverse cardiovascular events(1 month post-procedure)
研究者
Remon Saleh Adly
Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.
Sohag University