Determining intestinal metaplasia and dysplasia in obese patients candidate for surgery

Early Phase 1

Completed

• Conditions: Condition 1: Obesity and sleep apnea. Condition 2: Obesity. Condition 3: all types of obesity. Condition 4: Morbid obesity.; Extreme obesity with alveolar hypoventilation; Obesity due to excess calories; Simple obesity NOS; Morbid obesity

• Registration Number: IRCT201305204811N3
• Lead Sponsor: Vice chancellor for research, Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 174

Inclusion Criteria

Morbid obese patients (BMI > 35 kg/m2), aged between 18 and 70 years old who are not involved in any other interventional study, have tendency for doing upper endoscopy and gastric biopsy.
Exclusion criteria: Cases with any severe diseases of kidney and heart and any other end stage diseases.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gastric dysplasia. Timepoint: At the beginning of study. Method of measurement: gastric biopsy.;Mucosal atrophy. Timepoint: At the beginning of study. Method of measurement: gastric biopsy.;H. pylori infection. Timepoint: At the beginning of study. Method of measurement: gastric biopsy.;Gastric metaplasia. Timepoint: At the beginning of study. Method of measurement: gastric biopsy.;Chronic gastritis. Timepoint: At the beginning of study. Method of measurement: gastric biopsy.;Reactive atypia of glandular epithelium. Timepoint: At the beginning of study. Method of measurement: gastric biopsy.

Secondary Outcome Measures

Name	Time	Method
FBS. Timepoint: at the beginning of study. Method of measurement: ELISA.;TG. Timepoint: at the beginning of study. Method of measurement: ELISA.;Total Cholestrol, LDL, HDL. Timepoint: at the beginning of study. Method of measurement: ELISA.;CRP, ESR. Timepoint: at the beginning of study. Method of measurement: ELISA.