Quantitative Analysis Between Neuromuscular Blocking Agent and Motor Evoked Potential and Analysis of Risk Factors for the Coefficient of Variance of Motor Evoked Potential in Patients Undergoing Brain Tumor Removal Surgery: Population Approach
Overview
- Phase
- N/A
- Intervention
- Arm I (MEP)
- Conditions
- Brain Tumor
- Sponsor
- Gangnam Severance Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Amplitude of the motor evoked potential
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the motor evoked potential in patients undergoing brain tumor surgery using the population approach. Investigator will investigate the influence of the other factors such as the impedence, reactance, muscel amount, and age on the motor evoked potential.
Investigators
Dong Woo Han
Professor
Gangnam Severance Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective brain tumor surgery under the monitoring of the motor evoked potential
Exclusion Criteria
- •Central or peripheral neuromuscular disease
- •Sensory or motor nerve disorder
- •Allergy to propofol, remifentanil, and rocuronium
- •Patients with pacemaker
Arms & Interventions
rocuronium
Neuromuscular blockade will be performed using rocuronium.
Intervention: Arm I (MEP)
Outcomes
Primary Outcomes
Amplitude of the motor evoked potential
Time Frame: At intraoperative 0 hr from the start of the anesthetic induction
Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the start of the anesthetic induction.
Secondary Outcomes
- Amplitude of the motor evoked potential(At intraoperative 0 h from the opening of the dura)