MEP and Neuromuscular Blocker

Not Applicable

Completed

• Conditions: Brain Tumor
• Interventions: Drug: Arm I (MEP)

• Registration Number: NCT04768400
• Lead Sponsor: Gangnam Severance Hospital

Brief Summary

It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the motor evoked potential in patients undergoing brain tumor surgery using the population approach. Investigator will investigate the influence of the other factors such as the impedence, reactance, muscel amount, and age on the motor evoked potential.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-02-17
• Study First Submitted QC: 2021-02-22
• Study First Posted: 2021-02-24
• Study Start: 2021-03-09
• Primary Completion: 2022-05-13
• Study Completion: 2022-05-13
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-04
• Last Update Posted: 2023-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective brain tumor surgery under the monitoring of the motor evoked potential

Exclusion Criteria

1. Central or peripheral neuromuscular disease
2. Sensory or motor nerve disorder
3. Allergy to propofol, remifentanil, and rocuronium
4. Patients with pacemaker

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
rocuronium	Arm I (MEP)	Neuromuscular blockade will be performed using rocuronium.

Primary Outcome Measures

Name	Time	Method
Amplitude of the motor evoked potential	At intraoperative 0 hr from the start of the anesthetic induction	Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the start of the anesthetic induction.

Secondary Outcome Measures

Name	Time	Method
Amplitude of the motor evoked potential	At intraoperative 0 h from the opening of the dura	Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the opening of the dura.

Trial Locations

Locations (1)

GangnamSeverance Hospital; 🇰🇷 Seoul, Korea, Republic of