Effects of Olanzapine standard oral tablets and orally disintegrating tablets on gut hormones, glucose metabolism and pituitary hormones.
Completed
- Conditions
- engels: antipsychotic drugs, type 2 diabetes mellitus, insulin resistanceNederlands: antipsychoticum, diabetes mellitus type 2, insuline resistentie
- Registration Number
- NL-OMON29380
- Lead Sponsor
- H. Pijl, Department Endocrinology and Metabolism, Leiden University Medical Center, C4-R, P.O. Box 9600, RC Leiden, The Netherlands.Telefon number: 31 71 5263082e-mail adres: h.pijl@lumc.nl
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
1. Healthy men without a positive family history of schizophrenia;
2. Age between 20 and 40 yr.
Exclusion Criteria
1. Fasting plasma glucose > 6 mmol/L.
2. BMI > 26 kg/m2.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Antrhopometric measurements: BMI, WHR, Body composition.<br /><br>2. Indirect calorimetry: Resting energy expenditure, respiratory quotient, glucose and fat oxidation.<br /><br>3. Plasma concentrations: Insulin, glucose, FFA, TG, PYY, PP, GLP-1, GLP-2, OXM, CCK, Ghrelin, ACTH, cortisol, PRL, Adiponectin, Leptin.
- Secondary Outcome Measures
Name Time Method Physical activity.