Prevention of bacteremia following impacted lower third molar surgery: A randomized triple-blind controlled trial of 0.3% chlorhexidine mouthrinse and 2-g amoxicilli

Phase 1

Completed

• Conditions: Prevention of bacteremia following bony impacted mandibular third molar surgery; Mandibular third molar; Bacteremia; Chlorhexidine mouthrinse; Amoxicillin

• Registration Number: TCTR20210531006
• Lead Sponsor: Faculty of Dentistry, Prince of Songkla University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-11-28
• Study Start: 2021-05-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1.Healthy adult patient (20-30 years old)
2.Need of surgical removal of bony impacted mandibular 3rd molar, with partially erupted in oral cavity.
3.No known risk to bacterial endocarditis
4.No signs or symptoms of infection

Exclusion Criteria

1.Patients with current antibiotic treatment in the past 1 month
2.HbA1c level of 6.5% or higher
3.Patients using routine oral antiseptic mouthrinse
4.Patients using immunosuppressant
5.Patient allergic to chlorhexidine or amoxicillin

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bacteremia occurrence Before treatment, (BD:0), 30 seconds (BD:1), and 15 minutes (BD:2) following flap incision. BACTEC FX and MALDI-TOF MS

Secondary Outcome Measures

Name	Time	Method
Bacteria identification Before treatment, (BD:0), 30 seconds (BD:1), and 15 minutes (BD:2) following flap incision. Gram stain