In vivo evaluation of molecular tissue properties of enthesial structures using multispectral optoacoustic tomography (MSOT) and arthrosonography in patients with inflammatory joint diseases (psoriasis, psoriatic arthritis) (MAPSA).

Not Applicable

Recruiting

Conditions: L40
M07.3
Psoriasis
Other psoriatic arthropathies

Registration Number: DRKS00024360

Lead Sponsor: niversitätsklinikum Erlangen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 90

Inclusion Criteria

Adult male or female patients capable of giving consent
- Age 18 - 80 years
- Present informed consent to participate in the study.
- Group 1 PsA
o Diagnosis of PsO (clinical and/or histological)
o Diagnosis of PsA according to CASPAR criteria
- Group 2 PsO
o Diagnosis of PsO (clinical and/or histological)

Exclusion Criteria

- Pregnancy
- Heavy physical activity
- Other previous musculoskeletal disease (such as rheumatoid arthritis, osteoarthritis)
- Tumor disease, diabetes mellitus, cardiovascular disease, chronic kidney, gastrointestinal, or liver disease
- Group 1 PsA
o Pre-treatment or ongoing therapy with bDMARD and/or tsDMARD.
- Group 2 PsO
o Diagnosis/family history of rheumatic disease.
o tendon pain, joint swelling
o Pre-treatment or ongoing therapy with bDMARD and/or tsDMARD.
- Group 3 Healthy individuals
o diagnosis/family history of rheumatic disease
o Diagnosis of PsO/PsA
o tendon pain, joint swelling

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification and comparison of structural and biochemical patterns (optoacoustic spectra providing MSOT values by spectral unmixing) in the imaging of the enthesial complex of patients with psoriatic arthritis and psoriasis and healthy volunteers by MSOT.

Secondary Outcome Measures

Name	Time	Method
- To compare quantitative biochemical imaging of individual structures of the enthesial complex (tendons, ligaments, bursae, tendon attachments) on MSOT and corresponding ultrasound findings in clinically manifest vs. arthrosonographically detected enthesitis.<br>- Identify quantitative biochemical changes associated with individual enthesitis-defining ultrasound findings (e.g., tendon thickening, erosions, power Doppler signal, bursitis).