Comparision of three different doses of nalbuphine which is added to to Intrathecal hyperbaric bupivacaine in patients undergoing knee joint surgeries.

Phase 2

Not yet recruiting

• Conditions: Unspecified internal derangement of knee,

• Registration Number: CTRI/2019/08/020916
• Lead Sponsor: Kalinga institute of medical sciences

Brief Summary

Spinal anesthesia is most commonly used technique  for lower limb surgries as it is very economical and easy to administer .However,postoperative pain control is a major concern because spinal anesthesia using only local anesthetics is associated with relatively shorter duration of action and thus early analgesic intervention is needed in postoperative period.

Various adjuvants are used to improve quality,prolong the duration of neuronal blockade and postoperative analgesia.

Nalbuphine is a  semi-synthetic opioid used as an adjuvant to sub-arachnoid blockade.

The main purpose of this study is to compare three different doses of nalbuphine and determine the optimum dose with maximum analgesic effect and mininal side-effects.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-09
• Last Update Posted: 2019-08-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

American society of anesthesiologists (ASA) Physical status I and II,patient posted for surgery of knee joint.

Exclusion Criteria

ASA PH III and IV,Height<150cm,BMI>30,Contraindication to spinal anesthesia,H/o adverse reactions to opioids,pregnancy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the optimum dose of nalbuphine with maximum analgesic and minimal side-effects.	Asessed every 15mins postoperatively till the patient receives first dose of rescue analgesia.

Secondary Outcome Measures

Name	Time	Method
Duration of onset and regression of snsory and motor blockade.	sennsory and motor status will be checked every 2 minutes after spinal injection for first 10 minutes,every 5 minutes for next 30 minutes,and 15mins till regression.

Trial Locations

Locations (1)

Kalinga institute of medical sciences; 🇮🇳 Khordha, ORISSA, India

Kalinga institute of medical sciences

🇮🇳Khordha, ORISSA, India

DrKUSUMANCHI RANJITHA

Principal investigator

9701604525

kusumanchiranjitha@gmail.com