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Clinical Trials/CTRI/2025/09/094307
CTRI/2025/09/094307
Not yet recruiting
Not Applicable

Effect of intermittent versus bolus enteral feeding on feeding tolerance among critically ill patients at a tertiary care centre, Puducherry- A Randomized Controlled Trial

Intramural Research Fund Committee, JIPMER1 site in 1 country168 target enrollmentStarted: September 17, 2025Last updated:

Overview

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Intramural Research Fund Committee, JIPMER
Enrollment
168
Locations
1
Primary Endpoint
To assess the effectiveness of intermittent versus bolus feeding on enteral feeding tolerance of critically ill patient

Overview

Brief Summary

This study is a randomized controlled trial on the effect of intermittent versus bolus enteral feeding on feeding tolerance among critically ill patients at JIPMER Puducherry. Patients who meet the inclusion criteria will be divided into two groups through block randomization.

Preparatory phase includes elevating the head of the bed at least 45 degrees to prevent aspiration and preparing articles required for intermittent and bolus feeding. Placement of tube will be confirmed by aspiration and air insufflation with stethoscope.

In intermittent feeding the targeted amount will be given through a feeding bag hung above the bed using a roller controller for one hour. In bolus feeding a syringe will be connected to the nasogastric tube and the feed will be given within 5 to 10 minutes followed by flushing with water.

Feeds will be given six times daily for five days. Gastric residual volume will be checked before every feed using a syringe. If residual volume is more than 50 percent of previous feed or above 250 ml the next feed will be withheld. If volume is below 250 ml it will be discarded and the next feed will be given.

Outcome measure will include gastric residual volume, abdominal distention, vomiting, diarrhea, constipation and achievement of targeted nutrition. Patients will be observed in semi fowlers or elevated position after feeding to reduce regurgitation and aspiration.

Study Design

Study Type
Interventional
Allocation
Randomized
Masking
None

Eligibility Criteria

Ages
18.00 Year(s) to 65.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • Mechanically ventilated patients
  • Patients admitted to the Critical Care ICU of JIPMER, Puducherry
  • Inability to swallow food orally and having indication for nasogastric tube feeding
  • Hemodynamically stable patients.

Exclusion Criteria

  • Development of ability to eat orally during the study
  • Need for any urgent diagnostic or therapeutic procedure that requires nil per oral
  • Presence of fistula, obstruction and surgery of the gastrointestinal system.

Outcomes

Primary Outcomes

To assess the effectiveness of intermittent versus bolus feeding on enteral feeding tolerance of critically ill patient

Time Frame: 1 year

Secondary Outcomes

  • - To assess the effectiveness of intermittent vs bolus enteral feeding methods i achieving targeted nutrition(- To associate the effectiveness of intermittent vs bolus feeding on enteral feeding tolerance with the clinical characteristics of the patients.)

Investigators

Sponsor
Intramural Research Fund Committee, JIPMER
Sponsor Class
Research institution and hospital
Responsible Party
Principal Investigator
Principal Investigator

Dr Lakshmi Ramamoorthy

College of Nursing, JIMPER

Study Sites (1)

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