Study on effect of yoga on autonomic nervous system in hypothyroid patients

Completed

• Conditions: Hypothyroidism, unspecified,

• Registration Number: CTRI/2019/12/022482
• Lead Sponsor: Jawaharlal Institute of Post graduate Medical Education and Research

Brief Summary

This study is an interventional study which studies effect of yoga therapy on hypothyroid patients in addition to thyroid supplementation. From rural and urban population from Puducherry and nearby districts of Tamilnadu ,the participants attending Endocrinology OPD in JIPMER will be screened and a detailed history will be obtained. After meeting the inclusion and exclusion criteria, the participants will be divided into two groups ( Intervention group and Control group) based on computer generated sequence .5 ml of fasting blood sample will be collected for biochemical analysis, following which breakfast will be provided to them. After breakfast , heart rate variability and baroreceptor sensitivity will be recorded.Then yoga therapy will be given in ACYTER (Advanced Center of Yoga Therapy and Educational Research) as per the protocol, three times in a week for Intervention group. The participants in the Yoga group are advised to practise Yoga for a period of three months. After three months ,the primary outcome heart rate variability and baroreceptor sensitivity and secondary outcomes like TNF- alpha, IL-6 ,total oxidant and antioxidant  level will be taken in both groups and will be compared.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-12-23
• Study Completion: 2020-09-15
• Last Update Posted: 2021-07-06

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

Hypothyroid patients of both genders belonging to age group of 18 to 50 with TSH value below 10 units will be included in study.

Exclusion Criteria

Diabetes Mellitus, Hypertension, Heart disease, Autonomic Dysfunction Those taking Chronic Drugs that can influence autonomic function, Those doing Yoga Practice.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
expected difference in mean of total power of heart rate variablity is 3.4	Improvement in total power of heart rate variablity in hypothyroid patients undergoing yoga therapy at end of three month (12 weeks ) from baseline recording

Secondary Outcome Measures

Name	Time	Method
improvises the thyroid profile,lipid profile, antioxidant level and lowers the oxidative stress and inflammatory markers like IL-6,TNF -Alpha in hypothyroid patients undergoing yoga therapy.	Three months of yoga therapy reduces the inflammatory markers and oxidative stress.

Trial Locations

Locations (1)

JIPMER , puducherry; 🇮🇳 Pondicherry, PONDICHERRY, India

JIPMER , puducherry

🇮🇳Pondicherry, PONDICHERRY, India

Dr Pravati Pal

Principal investigator

9360682406

drpravatipal@gmail.com