The Mental Health Associations With Vitiligo: a Population-based Cohort Study in the UK
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36,104
- 试验地点
- 1
- 主要终点
- Number of Participants With Depressive Episodes
研究概览
简要总结
This cohort study is a large population-based study in the UK to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with vitiligo compared to controls and to evaluate whether the relative risks may vary by different ethnicity.
详细描述
This study has two primary outcomes 1) Prevalence and incidence of mental health condtions in people diagnosed with vitiligo compared to matched controls and 2) Primary care and secondary healthcare utilisation in patients diagnosed with vitiligo and having a prevalent depressive conditon compared to matched controls. In addition, the study examines risk of time off work and unemployment in people diagnosed with vitiligo compared to matched controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All eligible adults ≥18 (as at date of vitiligo diagnosis for cases or start of follow-up for controls) registered with GP practices contributing data to OPCRD between January 1, 2004 and December 31, 2020, were eligible for inclusion in the study.
排除标准
- •People with less than 1 year of follow up available
结局指标
主要结局
Number of Participants With Depressive Episodes
时间窗: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Prevalence of common mental health conditions (depressive episodes) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Risk of Anxiety Disorder Within Adult Patients With Vitiligo
时间窗: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
Adjusted hazard ratio calclulated using Cox Proportional hazard models
Risk of Depressive Episodes Within Adult Patients With Vitiligo
时间窗: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
Adjusted hazard ratio calculated using Cox proportional hazards models
Number of Participants With Anxiety Disorder
时间窗: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Prevalence of common mental health conditions (Anxiety Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Number of Participants With Recurrent Depressive Disorder
时间窗: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Prevalence of common mental health conditions (Recurrent Depressive Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Risk of Recurrent Depressive Disorder Within Adult Patients With Vitilgo
时间窗: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
Adjusted hazard ratio calculated using Cox proportional hazards models. Adjusted for age, gender, ethnicity, social deprivation quintile, body mass index, smoking status, alcohol use and comorbidities (hypertension, hyperlipidaemia, type 2 diabetes, atrial fibrillation, angina, myocardial infarction, heart failure, stroke, chronic kidney disease stages 3-5, chronic obstructive pulmonary disease, asthma, chronic liver disease and dementia).
次要结局
未报告次要终点