The Effect of Cognitive Functions on Upper Extremity Functionality in Parkinson's Patients

Not Applicable

Completed

• Conditions: Upper Extremity Problem; Functional Disturbance; Cognitive Impairment; Parkinson
• Interventions: Diagnostic Test: clinical assessment

• Registration Number: NCT05872646
• Lead Sponsor: Pamukkale University

Brief Summary

Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.

Detailed Description

Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. Involvement of nigrostriatal dopaminergic neurons is associated with the motor manifestations of the disease. The most common of these symptoms are; resting tremor, bradykinesia, rigidity and balance disorder. However, non-motor symptoms related to the involvement of nervous system structures other than the dopaminergic nigrostriatal system can be observed in PD. However, due to the predominance of motor symptoms in PD, it took many years to notice cognitive changes. Traditionally, cognitive impairments in PD have been expected to occur in the advanced stages of the disease. However, cognitive impairments in the early stages are reported in approximately 30-35% of patients. Cognitive dysfunction is defined in PD, ranging from mild impairments in certain cognitive domains to severe dementia. Cognitive impairment primarily affects executive and visuospatial functions, and memory is secondarily affected.

Executive functions are higher cognitive processes that use and modify information from many cortical sensory systems in the fore and hindbrain areas to modulate and teach behavior. The frontal cortex, especially the prefrontal cortex and its striatal connections are very important neuroanatomical regions for executive functions. The relationship between the effects of cognition and motor performance and parameters in groups such as the elderly, PD and Alzheimer's patients in which these centers are affected has been an issue that has attracted the attention of many researchers. Most of the studies have focused on the lower extremity performance of cognition. However , it has been reported that cognition has positive effects on upper extremity performance and early acquired upper extremity skills have positive effects on cognitive performance .

The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.

Study Timeline

• Study Start: 2018-02-08
• Primary Completion: 2023-03-10
• Study Completion: 2023-03-10
• Study First Submitted: 2023-03-10
• Status Verified: 2023-05
• Study First Submitted QC: 2023-05-14
• Last Update Submitted: 2023-05-14
• Study First Posted: 2023-05-24
• Last Update Posted: 2023-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

• Having a diagnosis of Parkinson's Disease.
• Not having hearing and vision problems.
• To be able to take the commands required for the manual dexterity tests.
• Agree to participate in the study.

Exclusion Criteria

• Having undergone musculoskeletal surgery for the upper extremity.
• Having vision and hearing problems.
• Having an additional disease that may affect cognitive tests.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
healthy group	clinical assessment	age-gender matched healthy group
patient group	clinical assessment	parkınson patient group

Primary Outcome Measures

Name	Time	Method
Unified Parkinson's Disease Rating Scale	1 year	Used for the evaluation of clinical manifestations of Parkinson's disease
Modified Hoehn Yahr Scale	1 year	Used for clinical staging of Parkinson's disease
Parkinson's Disease Questionnaire-PDQ 39	1 year	Used to assess the quality of life of Parkinson's patients

Secondary Outcome Measures

Name	Time	Method
Nine Hole Peg Test	1 year	To assess manuel dexterity
Dexterity Questionnaire-24	1 year	To assess manuel dexterity
Stroop Test	1 year	measures the selective attention ability of individuals
Wechsler Memory Scale-Revised	1 year	To assess attention, learning, memory and working memory in individuals aged 16-89

Trial Locations

Locations (1)

Pamukkale Unıversity; 🇹🇷 Denizli, Turkey