A Prospective Randomized Controlled Clinical Study on the Effect of Oral Maltodextrin Administration Versus Conventional Fasting in the Preoperative Period Among Patients Undergoing ENT Surgeries Under General Anaesthesia

Prolonged preoperative fasting can lead to catabolic metabolism, muscle breakdown, insulin resistance, hyperglycemia, discomfort, and increased metabolic stress.

Preoperative carbohydrate (CHO) loading, especially with maltodextrin, counters these effects by improving insulin sensitivity, reducing stress response, stabilizing hemodynamics, and increasing patient comfort.

Aim— To evaluate the effect of preoperative oral maltodextrin loading on hemodynamic stability in patients undergoing general anaesthesia.

Primary Objective--Compare hemodynamic changes (HR, BP, MAP) between maltodextrin-loaded patients and conventionally fasted patients.

Secondary Objective--Assess hunger, thirst, and overall satisfaction before induction.

All eligible patients will be screened for inclusion and informed consent was obtained. Participants were then randomly allocated into Group A or Group B. Preoperative hunger, thirst, and satisfaction scores were recorded for all patients. In the operating room, standard ASA monitoring was applied, and a uniform general anaesthesia technique was used, consisting of glycopyrrolate, midazolam, and fentanyl followed by induction with propofol and muscle relaxation with atracurium. Anaesthesia was maintained using sevoflurane. Hemodynamic parameters were monitored at baseline, after induction, every 2 minutes for the first 10 minutes, every 5 minutes until 30 minutes, and subsequently every 15 minutes until the end of surgery. At the conclusion of the procedure, standard reversal of neuromuscular blockade was administered.