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Clinical Trials/NCT05092737
NCT05092737CompletedNot Applicable

Physiological Response to Prone Position in Intubated Adults With COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): a Retrospective Study

University of Lausanne Hospitals1 site in 1 country31 target enrollmentStarted: August 1, 2021Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
31
Locations
1
Primary Endpoint
PaO2/FiO2
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Retrospective study in COVID-19 ARDS patients hospitalised in the ICU. Investigators aim to explore the effects of prone positioning on oxygenation, dead space ventilation and mortality.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •COVID-19 associated moderate to severe ARDS
  • •Invasive mechanical ventilation
  • •Prone positioning
  • •admitted to ICU

Exclusion Criteria

  • •already sustained prone positioning in referring hospital
  • •pronation during ECMO only
  • •denied consent for data analysis

Outcomes

Primary Outcomes

PaO2/FiO2

Time Frame: Within 2 hours before pronation and 2 hours before supination

Arterial partial pressure of oxygen / Fraction of inspired oxygen

Secondary Outcomes

  • Ventilatory Ratio(Within 2 hours before pronation and 2 hours before supination)
  • Alveolo-arterial oxygen gradient change(Within 2 hours before pronation and 2 hours before supination)
  • Mortality or Extracorporeal membrane oxygenation (ECMO) support(Once between ICU admission and extubation)

Investigators

Sponsor
University of Lausanne Hospitals
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Piquilloud Imboden Lise

Principal Investigator

University of Lausanne Hospitals

Study Sites (1)

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